After an acute myocardial infarction, which enzyme is the first to become elevated?

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Multiple Choice

After an acute myocardial infarction, which enzyme is the first to become elevated?

Explanation:
When heart-muscle cells are damaged in an acute myocardial infarction, enzymes leak into the bloodstream. The first to rise among the options is the CK enzyme, specifically the CK-MB isoenzyme, which is enriched in cardiac tissue. This early appearance reflects how quickly CK-MB leaks from injured cardiomyocytes after membrane disruption. CK-MB becomes detectable about 3–6 hours after onset, peaks around 24 hours, and returns to baseline within a couple of days. The other enzymes (LD, AST) rise later as injury progresses, and ALT is not a reliable marker for myocardial injury. So, the earliest elevated marker after MI is CK-MB.

When heart-muscle cells are damaged in an acute myocardial infarction, enzymes leak into the bloodstream. The first to rise among the options is the CK enzyme, specifically the CK-MB isoenzyme, which is enriched in cardiac tissue. This early appearance reflects how quickly CK-MB leaks from injured cardiomyocytes after membrane disruption. CK-MB becomes detectable about 3–6 hours after onset, peaks around 24 hours, and returns to baseline within a couple of days. The other enzymes (LD, AST) rise later as injury progresses, and ALT is not a reliable marker for myocardial injury. So, the earliest elevated marker after MI is CK-MB.

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