Angiotensin II stimulates the adrenal cortex to produce which hormone?

• A. Aldosterone
• B. Cortisol
• C. Adrenaline
• D. DHEA

Answer: (A)

Angiotensin II stimulates aldosterone production in the adrenal cortex. In the renin-angiotensin system, renin release leads to the formation of angiotensin II, which acts on the zona glomerulosa of the adrenal cortex via AT1 receptors. This signaling increases calcium within those cells and activates enzymes that synthesize aldosterone. Aldosterone then travels to the kidneys, where it promotes sodium reabsorption and potassium secretion in the distal tubules and collecting ducts, helping to raise blood volume and pressure.

Cortisol is mainly produced in the zona fasciculata under ACTH stimulation, adrenaline is released from the adrenal medulla in response to sympathetic signals, and DHEA from the zona reticularis is also primarily ACTH-regulated. These pathways are distinct from the angiotensin II–driven production of aldosterone.