In amniotic fluid, the procedure used to detect hemolytic disease of the newborn is:

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Multiple Choice

In amniotic fluid, the procedure used to detect hemolytic disease of the newborn is:

Explanation:
In hemolytic disease of the newborn, bilirubin from fetal red cell destruction accumulates in the amniotic fluid. Bilirubin absorbs light strongly at about 450 nm, so measuring the optical density at 450 nm in amniotic fluid with a spectrophotometer provides a bilirubin concentration. This bilirubin measurement is historically used to assess disease severity and guide management via the Liley chart. The other options don’t detect HDN: creatinine reflects fetal kidney function, the lecithin/sphingomyelin ratio assesses fetal lung maturity, and estriol is a maternal screening marker not related to amniotic fluid bilirubin.

In hemolytic disease of the newborn, bilirubin from fetal red cell destruction accumulates in the amniotic fluid. Bilirubin absorbs light strongly at about 450 nm, so measuring the optical density at 450 nm in amniotic fluid with a spectrophotometer provides a bilirubin concentration. This bilirubin measurement is historically used to assess disease severity and guide management via the Liley chart. The other options don’t detect HDN: creatinine reflects fetal kidney function, the lecithin/sphingomyelin ratio assesses fetal lung maturity, and estriol is a maternal screening marker not related to amniotic fluid bilirubin.

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