What is the active liver metabolite of procainamide?

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Multiple Choice

What is the active liver metabolite of procainamide?

Explanation:
Procainamide is processed in the liver by acetylation to N-acetylprocainamide, the active metabolite. This metabolite continues to exert antiarrhythmic effects, often with a longer duration of action due to its longer half-life. Because NAPA contributes to the overall therapeutic and toxic effects, understanding its role is important for dosing and monitoring, especially in individuals who acetylate more slowly and can accumulate more NAPA. The other compounds listed are separate drugs not formed from procainamide by hepatic metabolism.

Procainamide is processed in the liver by acetylation to N-acetylprocainamide, the active metabolite. This metabolite continues to exert antiarrhythmic effects, often with a longer duration of action due to its longer half-life. Because NAPA contributes to the overall therapeutic and toxic effects, understanding its role is important for dosing and monitoring, especially in individuals who acetylate more slowly and can accumulate more NAPA. The other compounds listed are separate drugs not formed from procainamide by hepatic metabolism.

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