Which enzymes are elevated in liver and hepatobiliary diseases according to the material?

• A. 5'-Nucleotidase and Gamma-Glutamyl Transferase
• B. Amylase and Lipase
• C. ALT and AST
• D. CK and LD

Answer: (A)

In liver and hepatobiliary disease, enzymes tied to bile formation and flow rise. Gamma-glutamyl transferase is located in biliary epithelium and increases with cholestasis or biliary obstruction, making it a liver-specific signal. 5'-Nucleotidase behaves similarly, rising in hepatobiliary disturbances and helping confirm that an elevated alkaline phosphatase is of liver origin rather than bone. Together, they point to hepatic involvement. Other enzymes serve different clues: amylase and lipase indicate pancreatic issues; ALT and AST show hepatocellular injury but are not as specific for cholestasis; CK and LD reflect muscle or other tissues. Hence, the elevation of 5'-nucleotidase and GGT aligns best with liver and hepatobiliary disease.