Which LD isoenzyme fraction is typically elevated in hepatic damage?

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Multiple Choice

Which LD isoenzyme fraction is typically elevated in hepatic damage?

Explanation:
Lactate dehydrogenase isoenzyme patterns tell you which tissue is releasing the enzyme when damage occurs. LD5 is the isoenzyme most abundant in liver (and also in skeletal muscle), so when hepatocytes are injured, LD5 is released into the blood and becomes the predominant elevated fraction. The other isoenzymes differ in tissue distribution—LD1 and LD2 are richer in heart and red blood cells, LD3 is more associated with lung tissue, and LD4/LD5 include liver/muscle activity—but the hallmark of hepatic injury is a rise in LD5. So, the fraction you’d most expect to be elevated with liver damage is LD5.

Lactate dehydrogenase isoenzyme patterns tell you which tissue is releasing the enzyme when damage occurs. LD5 is the isoenzyme most abundant in liver (and also in skeletal muscle), so when hepatocytes are injured, LD5 is released into the blood and becomes the predominant elevated fraction. The other isoenzymes differ in tissue distribution—LD1 and LD2 are richer in heart and red blood cells, LD3 is more associated with lung tissue, and LD4/LD5 include liver/muscle activity—but the hallmark of hepatic injury is a rise in LD5. So, the fraction you’d most expect to be elevated with liver damage is LD5.

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